Hereditary Cancer Screening

Benefits of this screening: 

1. Improves understanding about cancer risk to guide medical decisions about the best way to manage their risk
2. Helps your relatives understand and manage their risk for cancer
3. provides information to help people who have been diagnosed with cancer make treatment decisions, including treatment with targeted therapies.

According to World Health Organization (WHO), Cancer is the second leading cause of death globally, and is responsible for an estimated 9.6 million deaths in 2018. Globally, about 1 in 6 deaths is due to cancer.

Most common hereditary cancers (ranked according to total number of deaths among cancers in 2018) ☠️︰
1.Colorectum (880 792, #2)
2. Stomach (780 685, #3)
3. Breast (626 679, #5)
4. Pancreas (432 242, #7)
5. Prostate (358 989, #8)
6. Ovary (184 799, #14)
7. Kidney (175 098, #16)
8. Corpus Uteri (89 929, #20)
9. Melanoma of skin (60 712, #22)
10. Thyroid (41 071, #24)

Common Mutations: 

BRCA1 and BRCA2 are the most common genes responsible for hereditary breast and ovarian cancers, they also increase the risk for other cancers, such as male breast cancer, pancreatic cancer, prostate cancer, and melanoma.

The five genes most commonly responsible for hereditary colorectal and endometrial cancer are also known as Lynch Syndrome genes. Mutations in these genes can also increase the risk for ovarian, stomach, pancreatic and other cancers. Mutations in two of the Lynch Syndrome genes have also been linked to increased risk for breast cancer.

Other gene mutations have been discovered that increase the risk for these cancers including PALB2, CHEK2, ATM, BRIP1 and others.

Risk factors for Hereditary Cancers🕵🏻‍
Sometimes, a family are strongly linked to an inherited gene mutation that is part of a family cancer syndrome.

The features of a person’s personal or family medical history that, particularly in combination, may suggest a hereditary cancer syndrome include:

• Cancer was diagnosed at an unusually young age
• Several different types of cancer occurred in the same person
• Cancer in both organs in a set of paired organs, such as both kidneys or both breasts
• Several first-degree relatives (the parents, siblings, or children of an individual) have the same type of cancer (for example, a mother, daughter, and sisters with breast cancer); family members with breast or ovarian cancer; family members with colon cancer and endometrial cancer
• Unusual cases of a specific cancer type (for example, breast cancer in a man)
• The presence of birth defects that are known to be associated with inherited cancer syndromes, such as certain noncancerous (benign) skin growths and skeletal abnormalities associated with neurofibromatosis type 1.
• Several family members with cancer

Booking Procedure

For more details on the program, please click check-up items.